Resource Type

Journal Article 5

Year

2023 1

2009 2

Keywords

cell cycle 2

CDK 1

CDK4 1

FAT1 1

GTF2I 1

PROTAC 1

RNA interference 1

apoptosis 1

benzydamine 1

cyclin 1

cyclin-dependent kinase 2 1

cyclin-dependent kinase 4 1

cyclin-dependent kinase1 1

degrader 1

esophageal squamous cell carcinoma 1

extracellular vesicle 1

lentiviral vector 1

mesenchymal stem cell 1

molecular glue 1

patient-derived xenograft 1

open ︾

Search scope:

排序： Display mode:

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-downSpecifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affectingOur study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway

Keywords： benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

HTML PDF Collect

Discovery of small molecule degraders for modulating cell cycle

Frontiers of Medicine   Pages 823-854 doi: 10.1007/s11684-023-1027-5

Abstract: The selectivity, application, validation and the current state of each CDK degrader will be overviewedAdditionally, possible methods are discussed for the development of degraders for CDK members that stillOverall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein

Keywords： PROTAC     molecular glue     degrader     cell cycle     CDK     cyclin    

HTML PDF Collect

Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 287-291 doi: 10.1007/s11684-009-0050-5

Abstract: RNA interference (RNAi) was used to silence the expression of the murine cdk4 gene .Three cdk4-shRNAs of mouse and a negative sequence were designed.It was confirmed by polymerase chain reaction (PCR) and sequencing that three pairs of cdk4-shRNAs andThe cdk4-siRNA2 was the most effective in silencing cdk4.provides a potential tool for studying and treating cdk4-related diseases.

Keywords： cyclin-dependent kinase 4     RNA interference     plasmid     lentiviral vector    

HTML PDF Collect

The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 384-389 doi: 10.1007/s11684-009-0070-1

Abstract: In the present report, cyclin-dependent kinase1 (CDK1) siRNA was transfected into cells to silence theCDK1 gene expression and study its role in the cell cycle and cell apoptosis.The siRNA targeting CDK1 gene was chemically synthesized and transfected into Hela cells by lipofectamineThe expression levels of CDK1 gene and protein were examined by real-time quantitative polymerase chainCDK1 gene was successfully silenced by its siRNA, and the CDK1 protein expression level was decreased

Keywords： cyclin-dependent kinase1     siRNA interference     cell cycle     apoptosis    

HTML PDF Collect

Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid carcinoma

Frontiers of Medicine doi: 10.1007/s11684-023-0999-5

Abstract: EMT, and stemness maintenance by increasing the expression of FAT1 and facilitating the FAT1-mediated CDK4, our work suggests that GTF2I transferred by MSC-EVs confer antioncogenic effects through the FAT1/CDK4

Keywords： thyroid carcinoma     mesenchymal stem cell     extracellular vesicle     GTF2I     FAT1     CDK4    

HTML PDF Collect

Title Author Date Type Operation

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Discovery of small molecule degraders for modulating cell cycle

Journal Article

Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Journal Article

The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Journal Article

Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid carcinoma

Journal Article